From the latest chapter on UI design:
Even if you think (as the Netscape 6.0 engineers clearly do) that Alt+Left is not a good shortcut key for “Back”, there are literally millions of people out there who will try to use Alt+Left to go back, and if you refuse to do it on some general religious principle that Bill Gates is the evil Smurf Gargamel, then you are just gratuitously ruining your program so that you can feel smug and self-satisfied, and your users will not thank you for it.